Welcome to Moldimed.cz

moldimed.cz

The primary objective of the Center of competence for molecular diagnostics and personalized medicine, "MOLDIMED” is to achieve critical mass of experts, institutions, and knowledge in research, development, protection of IP, certification, technology transfer, and commercionalization of in vitro diagnostics, in order to create market oriented flexible national network in area of diagnostic, prognostic and predictive biomarkers and to enable further development of personalized medicine. The Center is supported from the Technological Agency of the Czech Republic (2014-2019).

The key goal of the MOLDIMED project is discovery, development and technology transfer of new knowledge in the translational biomedical sciences, particularly focusing on the biomarker and molecular diagnostics area. To achieve its goal, MOLDIMED will capitalize on existing close links among major academic institutions in the country represented by the Institute of Molecular and Translational Medicine at Palacký University in Olomouc, the Central European Institute of Technologies at Masaryk University in Brno, the Institute of Molecular Genetics of the Czech Academy of Sciences, IT4Innovations/VŠB-Technical University of Ostrava; major hospitals providing direct access to clinical material and potential clinical diagnostics trials – the University Hospital in Olomouc and the University Hospital in Brno; private enterprises involved in diagnostics, development and manufacturing of molecular diagnostics - Generi Biotech, s.r.o., IntellMed, s.r.o., Sofigen, s.r.o. and CGB, a.s. The project participants are willing to create a vehicle that will transform the way biomarker research is performed in the Czech Republic. Recognizing that no single institution alone can assemble the necessary resources, the consortium participants elected to enter into a collaborative partnership with the common goal of creating a functional network enabling productive R&D of molecular diagnostics and personalized medicine. The MOLDIMED model, enabling strategic alignment of individual strengths, lends itself to many other areas of scientific research and commercial exploitation. We believe that MOLDIMED has the potential to establish national and international leadership in niche areas where the Czech Republic has strong academic and industrial research as well as clinical expertise.

ABOUT IMTM

The Institute of Molecular and Translational Medicine (IMTM), Faculty of Medicine and Dentistry, Palacký University in Olomouc is a leading Czech translational medicine institute established in 2010. IMTM was established within the infrastructural project initiated by the Palacký University, in close partnership with the University Hospital in Olomouc, the Institute of Chemical Technology and the Institute of Organic Chemistry and Biochemistry, AS CR, v.v.i. in Prague. Our research at IMTM is focused on better understanding of human diseases and development of future medicines and diagnostics.

Moldimed Publications

2017

Impact Factor Journals

PETRÁČEK, M.; L. BRULÍKOVÁ; K. MOTYKA; J. HLAVÁČ. From Study of Catalytic Hydrogenation to Novel Ratiometric pH Indicators with Quinoline Scaffold.

ChemistrySelect. 2017, 2 (24), 7325-7331. ISSN: 2365-6549. IF: 0.000

OŽDIAN, T., D. HOLUB, Z. MACEČKOVÁ, L. VARANASI, G. RYLOVÁ, J. ŘEHULKA, J. VÁCLAVKOVÁ, H. SLAVÍK, P. MOUDRÝ, P. ZNOJEK, J. STANKOVÁ, J. DE SANCTIS, M. HAJDÚCH a P. DŽUBÁK. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells.

Journal of Proteomics. 2017, 162, 73 - 85. ISSN: 1874-3919. IF: 3.867. PMID: 28478306

OKOROCHENKOVA, Y. a J. HLAVÁČ. Novel ratiometric xanthene-based probes for protease detection.

Dyes and Pigments. 2017, 143 232-238. ISSN: 0143-7208. IF: 3.473

LIGASOVÁ, A., P. KONEČNÝ, I. FRYDRYCH a K. KOBERNA. Looking for ugly ducklings: The role of the stability of BrdU-antibody complex and the improved method of the detection of DNA replication.

PLOS One. 2017, 12 (3),e0174893. ISSN: 1932-6203. IF: 3.057. PMID: 28358913

LIGASOVÁ, A., P. KONEČNÝ, I. FRYDRYCH a K. KOBERNA. Cell cycle profiling by image and flow cytometry: The optimised protocol for the detection of replicational activity using 5-Bromo-2'-deoxyuridine, low concentration of hydrochloric acid and exonuclease III.

PLOS One. 2017, 12 (4), e0175880. ISSN: 1932-6203. IF: 3.057. PMID: 28426799

Patents

Agrawal, Khushboo. Method of predicting the tumor response to DNA methylation inhibitors and alternative therapeutic regimens for overcoming resistance.

Patent. Číslo: EP 2924125. Patent udělen: 17. 6. 2017.

Palacky university, Olomouc. Method of determination of cancer cell drug sensitivity towards aurora kinase inhibitors.

Patent. Number: JP 6144696. Issued: Japan Patent Offcie. Patentee: Palacky University, Olomouc. Institute of Animal Physiology and Genetics ASCR, V.V.I.. Filing date: 7. 12. 2012. Registration date: 19. 5. 2017.

2016

Impact Factor Journals

ŠIMKOVÁ, D., G. KHARAISHVILI, G. KOŘÍNKOVÁ, T. OŽDIAN, T. SUCHANKOVA-KLEPLOVA, T. SOUKUP, M. KRUPKA, A. GALANDÁKOVÁ, P. DŽUBÁK, M. JANÍKOVÁ, J. NAVRATIL, Z. KAHOUNOVA, K. SOUCEK a J. BOUCHALThe dual role of asporin in breast cancer progression.

Oncotarget. 2016, 7 (32), 52045-52060. ISSN: 1949-2553 . IF: 5.008. PMID: 27409832

SCHADICH, E., J. HLAVÁČ, T. VOLNÁ, L. VARANASI, M. HAJDÚCH a P. DŽUBÁK. Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes.

BioMed Research International. 2016, Article no. 2173275. ISSN: 2314-6133. IF: 2.134. PMID: 26942188

PAVLOUŠKOVÁ J., RÉBLOVÁ K., TICHÝ L., FREIBERGER T., FAJKUSOVÁ L.Functional analysis of the p.(Leu15Pro) and p.(Gly20Arg) sequence changes in the signal sequence of LDL receptor.

Atherosclerosis (2016); 250: 9-14.

NAVRKALOVÁ V., YOUNG E., BALIAKAS P., RADOVÁ L., SUTTON LA., PLEVOVÁ K., MASOURI L., LJUNGSTROM V., NTOUFA S., DAVIS Z., JULIUSSON G., SMEDBY K., BELESSI Ch., PANAGIOTIDIS P., TOULOUMENIDOU T., DAVI F., LANGERAK A., GHIA P., STREFFORD J., OSCIER D., MAYER J., STAMATOPOULOS K., POSPÍŠILOVÁ Š., ROSENQUIST R., TRBUŠEK MATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset 2 is associated with markedly short telomeres.

Haematologica (2016); 101(9): e369-e373.

KOUDELÁKOVÁ, V., R. TROJANEC, J. VRBKOVÁ, S. DONEVSKA, K. BOUCHALOVÁ, M. KOLÁŘ, L. VARANASI a M. HAJDÚCHFrequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort.

Genes, Chromosomes & Cancer. 2016, 55 (5), 409-17. ISSN: 1045-2257 . IF: 4.041. PMID: 26847577

KOPEČKOVÁ L., BUČKOVÁ H., KÝROVÁ J., GAILLYOVÁ R., NĚMEČKOVÁ J., JEŘÁBKOVÁ B., VESELÝ K., STEHLÍKOVÁ K., FAJKUSOVÁ L.Ten years of DNA diagnostics of epidermolysis bullosa in the Czech Republic

British Journal of Dermatology (2016); 174(6): 1388-1391.

KISS, I., J. MLCOCHOVA, Z. BORTLICEK, A. POPRACH, J. DRÁBEK, P. VYCHYTILOVA-FALTEJSKOVA, M. SVOBODA, T. BUCHLER, S. BATKO, A. RYSKA, M. HAJDÚCH a O. SLABÝEfficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients.

Anticancer Research. 2016, 36 (9), 7955-9. ISSN: 0250-7005 . IF: 1.895. PMID: 27630355

KANTOROVÁ B., MALČÍKOVÁ J., BRÁZDILOVÁ K., BORSKÝ M., PLEVOVÁ K., ŠMARDOVÁ J., RADOVÁ L., TOM N., TRBUŠEK M., DIVÍŠKOVÁ E., SKUHROVÁ FRANCOVÁ H., NAVRKALOVÁ V., DOUBEK M., BRYCHTOVÁ Y., MAYER J., POSPÍŠILOVÁ Š.: Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients. British Journal of Haematology (2016)

v tisku.

JEDINÁKOVÁ, P., P. SEBEJ, T. SLANINA, P. KLAN a J. HLAVÁČStudy and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles.

Chemical Communications. 2016, 52 (26), 4792-4795. ISSN: 1359-7345. IF: 6.834. PMID: 26956058

DRÁBEK, J., M. SMOLIKOVA, R. KALENDAR, F. LOPES PINTO, P. PAVLOUSEK, K. KLEPARNIK a I. FREBORT. Design and validation of an STR hexaplex assay for DNA profiling of grapevine cultivars.

Electrophoresis. 2016, 37 (23-24), 3059-3067. ISSN: 0173-0835 . IF: 2.482. PMID: 27696463

DRÁBEK, J.Surmounting PCR challenge using Contradictory matrix from Theory of Inventive Problem Solving (TRIZ).

SpringerPlus. 2016, 5 (1), 1-6. ISSN: 2193-1801 . IF: 0.982. PMID: 26835236

BUČKOVÁ H., NOSKOVÁ H., BORSKÁ R., RÉBLOVÁ K., PINKOVÁ B., ZAPLETALOVÁ E., KOPEČKOVÁ L., HORKÝ O., NĚMEČKOVÁ J., GAILLYOVÁ R., NAGY Z., VESELÝ K., HERMANOVÁ M., STEHLÍKOVÁ K., FAJKUSOVÁ L.Autosomal recessive congenital ichthyoses in the Czech republic.

British Jounal of Dermatology (2016); 174(2): 405-407.

BRULÍKOVÁ, L., Y. OKOROCHENKOVA a J. HLAVÁČ.A solid-phase synthetic approach to pH-independent rhodamine-type fluorophores.

Organic and Biomolecular Chemistry. 2016, 14 (44), 10437-10443. ISSN: 1477-0520. IF: 3.559. PMID: 27754510

BRULÍKOVÁ, L., S. KŘUPKOVÁ, M. LABORA, K. MOTYKA, L. HRADILOVÁ, M. MISTRÍK, J. BÁRTEK a J. HLAVÁČ. Synthesis and study of novel pH-independent fluorescent mitochondrial labels based on Rhodamine B.

RSC Advances. 2016, 6 (28), 23242-23251. ISSN: 2046-2069 . IF: 3.840.

BRHELOVA E, et al.Validation of Minim typing for fast and accurate discrimination of extended-spectrum, beta-lactamase-producing Klebsiella pneumoniae isolates in tertiary care hospital.

Diagnostic microbiology and infectious disease. Sep 2016;86(1):44-49.

BEZDICEK M, et al.Rapid detection of fungal pathogens in bronchoalveolar lavage samples using panfungal PCR combined with high resolution melting analysis.

Medical mycology. Oct 1 2016; 54(7):714-724.

Patents

MRÁZ, Marek, Kateřina ČERNÁ, Šárka POSPÍŠILOVÁ a Jiří MAYERZpůsob absolutní kvantifikace exprese miRNA, zejména miR-34a a/nebo miR-150, a jeho použití v diagnostice a prognostice B-buněčných malignit.

2016. Patent. Číslo: 306080. Vydavatel: Úřad průmyslového vlastnictví. Místo vydání: Praha. Název vlastníka: Masarykova univerzita, Brno, CZ; Fakultní nemocnice Brno, Brno - Bohunice, CZ. Datum registrace: 17. 2. 2015. Datum přijetí: 15. 6. 2016.

2015

Impact Factor Journals

LIGASOVÁ, A., D. STRUNIN, D. FRIEDECKÝ, T. ADAM a K. KOBERNAA fatal combination: a thymidylate synthase inhibitor with DNA damaging activity

PLOS One. 2015, 10(2), 1-21. ISSN 1932-6203. IF: 3.234. PMID: 25671308

LIGASOVÁ, A., R. LIBOSKA, I. ROSENBERG a K. KOBERNA.The Fingerprint of Anti- Bromodeoxyuridine Antibodies and Its Use for the Assessment of Their Affinity to 5-Bromo- 2'-Deoxyuridine in Cellular DNA under Various Conditions

PLOS One. 2015, 10(7), e0132393. ISSN 1932-6203. IF: 3.234. PMID: 26161977

FUNK, P., K. MOTYKA, P. DŽUBÁK, P. ZNOJEK, S. GURSKÁ, J. KUSZ, C. MCMASTER, M. HAJDÚCH a M. SOURAL.Preparation of 2-phenyl-3-hydroxyquinoline- 4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents

RSC Advances. 2015, 5(60), 48861-48867. ISSN 2046-2069. IF: 3.840.

KOUDELÁKOVÁ, V., J. BERKOVCOVÁ, R. TROJANEC, J. VRBKOVÁ, L. RADOVÁ, J. EHRMANN, Z. KOLÁŘ, B. MELICHAR a M. HAJDÚCHEvaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR Method

Journal of Molecular Diagnostic.2015, 17(4), 446-455. ISSN 1525-1578. IF: 3.955. PMID: 25956448

HEZOVA, R., A. KOVARIKOVA, J. SROVNAL, M. ZEMANOVÁ, T. HARUSTIAK, J. EHRMANN, M. HAJDÚCH, M. SVOBODA, M. SACHLOVA a O. SLABÝDiagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus

Diagnostic Pathology. 2015,10(-), Article Number: 42. ISSN 1746-1596. IF: 2.411. PMID: 25928282

SLABÝ, O., J. SROVNAL, L. RADOVÁ, J. GREGAR, J. JURACEK, P. LUŽNÁ, M. SVOBODA, M. HAJDÚCH a J. EHRMANNDynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma

Carcinogenesis. 2015, 36(5), 521-527. ISSN 0143-3334. IF: 5.266.PMID: 25784377

BOUCHALOVÁ, K., M. SVOBODA, G. KHARAISHVILI, J. VRBKOVÁ, J. BOUCHAL, R. TROJANEC, V. KOUDELÁKOVÁ, L. RADOVÁ, K. CWIERTKA, M. HAJDÚCH a Z. KOLÁŘBCL2 is an independent predictor of outcome in basal-like triplenegative breast cancers treated with adjuvant anthracycline-based chemotherapy.

Tumour Biology. 2015, 36(6), 4243-52. ISSN 1010-4283 . IF: 2.840. PMID: 25616695

RYLOVÁ, G., T. OŽDIAN, L. VARANASI, M. SOURAL, J. HLAVÁČ, D. HOLUB, P. DŽUBÁK a M. HAJDÚCHAffinity-Based Methods in Drug-Target Discovery

Current Drug Targets. 2015, 16(1), 60-76. ISSN 1389-4501. IF: 3.597. PMID: 25410410

NAVRKALOVÁ V, KANTOROVÁ B, JAROŠOVÁ M, POSPÍŠILOVÁ Š.Molecular Prognostic Markers and Their Clinical Relevance in Chronic Lymphocytic Leukemia

BUČKOVÁ H, NOSKOVÁ H, BORSKÁ R, RÉBLOVÁ K, PINKOVÁ B, ZAPLETALOVÁ E, KOPEČKOVÁ L, HORKÝ O, NĚMEČKOVÁ J, GAILLYOVÁ R, NAGY Z, VESELÝ K, HERMANOVÁ M, STEHLÍKOVÁ K, FAJKUSOVÁ L.Autosomal recessive congenital ichthyoses in the Czech Republic

KOPEČKOVÁ L, BUČKOVÁ H, KÝROVÁ J, GAILLYOVÁ R, NĚMEČKOVÁ J, JEŘÁBKOVÁ B, VESELÝ K, STEHLÍKOVÁ K, FAJKUSOVÁ L.Ten years of DNA diagnostics of epidermolysis bullosa in the Czech Republic

UVIROVA M, SIMOVA J, KUBOVA B, DVORACKOVA N, TOMASKOVA H, SEDIVCOVA M, DITE P.Comparison of the prevalence of KRAS-LCS6 polymorphism (rs61764370) within different tumour types (colorectal, breast, non-small cell lung cancer and brain tumours). A study of the Czech population.

Other Reviewed Journals

DRABEK, J.40 Inventive Principles for Genetic Diagnostic Laboratories

The Triz Journal. 2015

ONDRYÁŠOVÁ, H., V. KOUDELÁKOVÁ, J. DRÁBEK, P. VANEK, R. SLAVKOVSKÝ a M. HAJDÚCHPilotní studie pro využití samoodběrové soupravy a molekulární diagnostiky HPV infekce pro skrínink karcinomu děložního čípku-

2014

Impact Factor Journals

UVIROVA M., SIMOVA J., KUBOVA B., DVORACKOVA N., TOMASKOVA H., SEDIVCOVA M., DITE P.Comparison of the prevalence of KRAS-LCS6 polymorphism (rs61764370) within different 2 tumour types (colorectal, breast, non-small cell lung cancer and brain tumours). A study of the 3 Czech population

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Sep;159(3):466-71. doi: 10.5507/bp.2015.029. Epub 2015 Jun 11.

RYLOVÁ, G., T. OŽDIAN, L. VARANASI, M. SOURAL, J. HLAVÁČ, D. HOLUB, P. DŽUBÁK a M. HAJDÚCHAffinity-Based Methods in Drug-Target Discovery

Current Drug Targets. 2015, 16(1), 60-76. ISSN 1389-4501. IF: 3.597. PMID: 25410410

BOUCHALOVÁ, K., G. KHARAISHVILI, J. BOUCHAL, J. VRBKOVÁ, M. HOUDOVÁ MEGOVÁ a A. HLOBILKOVATriple Negative Breast Cancer - BCL2 in Prognosis and Prediction

Current Drug Targets.. 2014, 15 (12), 1166-1175.ISSN: 1389-4501. IF: 3.597. PMID: 25374001

HOUDOVÁ MEGOVÁ , M., J. DRÁBEK, V. KOUDELÁKOVÁ, R. TROJANEC, O. KALITA a M. HAJDÚCHIsocitrate Dehydrogenase 1 and 2 Mutations in Gliomas

Journal of Neuroscience Research. 2014, 92 (12), 1611-1620. ISSN: 0360-4012. IF: 2.729. PMID: 25078896

Other Reviewed Journals

SPENEROVA, M., J. SROVNAL, J. POTĚŠIL, M. HAJDÚCH, V. MIHÁL a P. DŽUBÁK.Historie glukokortoidní terapie v léčbě leukémií u dětí

Česko-slovenská pediatrie. 2014, 69(6), 350-362. ISSN 0069-2328.

Contact informations:

Institute of Molecular and Translational Medicine,
Faculty of Medicine and Dentistry,
Palacky University Olomouc,
Hněvotínská 1333/5,
779 00 Olomouc,
Czech Republic

Reception:
Tel.: +420 585632111
Fax: +420 585632180
Email: reception@imtm.upol.cz